Gly-Arg-Gly-Asp-Asn-Pro

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Gly-Arg-Gly-Asp-Asn-Pro

SynonymsGRGDNP; GLY-ARG-GLY-ASP-ASN-PRO
DescriptionG-R-G-D-N-P is a superior inhibitor of cell attachment to fibronectin and a weak inhibitor of cell attacment to vitronectin. It also inhibits binding of fibrinogen, fibronectin, vitronectin and von Willebrand factor to platelets and resists to carboxypeptidases. G-R-G-D-N-P induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. It contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. G-R-G-D-N-P inhibits cell adhesion to fibronectin 80-90% at 1 mM.
Cas No114681-65-1
序列
{GLY}{ARG}{GLY}{ASP}{ASN}{PRO}
Sequence ShorteningGRGDNP
Molecular FormulaC23H38N10O10
Molecular Weight614.6
纯度> 95%
FormLyophilized
StorageStore at -20°C. Keep tightly closed. Store in a cool dry place.